When Sherlock Holmes turns down the case of persecuted Laura Shirley, Mrs Hudson - the landlady of Baker Street - and Mary Watson - the wife of Dr Watson - resolve to take on the investigation themselves. From the kitchen of 221b, the two women begin their inquiries and enlist the assistance of the Baker Street Irregulars and the infamous Irene Adler. A trail of clues leads them to the darkest corners of Whitechapel, where the fearsome Ripper supposedly still stalks. They soon discover Laura Shirley is not the only woman at risk - the lives of many others are in danger too. As Mrs Hudson and Mary Watson put together the pieces of an increasingly complex puzzle, the investigation becomes bigger than either of them could ever have imagined. Can they solve the case or are they just pawns in a much larger game?