Deux intrigues sentimentales principales, l'histoire des deux mariages de Dorothea et le mariage malheureux de Lydgate, jeune médecin ambitieux, avec la vulgaire Rosamond Vincy, se détachent sur un fond foisonnant de personnages et d'événements, d'épisodes intéressants, amusants, émouvants.

George Eliot's most ambitious novel is a masterly evocation of diverse lives and changing fortunes in a provincial community. Peopling its landscape are Dorothea Brooke, a young idealist whose search for intellectual fulfillment leads her into a disastrous marriage to the pedantic scholar Casaubon; the charming but tactless Dr Lydgate, whose marriage to the spendthrift beauty Rosamund and pioneering medical methods threaten to undermine his career; and the religious hypocrite Bulstrode, hiding scandalous crimes from his past. As their stories interweave, George Eliot creates a richly nuanced and moving drama, hailed by Virginia Woolf as 'one of the few English novels written for adult people'.